MetalDrug operates at the frontier of deterministic molecular engineering. MDC, FDC, and the Moleculogic Engine function as a tiered, logic-verified simulation and generation platform — where every compound is traceable to its original logic blueprint.
"logic_gates": [ { "type": "AND", "inputs": [ { "trigger": "pH", "condition": "<", "threshold": 6.5 }, { "trigger": "ROS", "condition": ">", "threshold": 100 } ], "output": "ligand_release" } ], "metal_center": { "element": "Zn", "coordination": "octahedral" }, "scoring": { "entropy_class": "B+", "risk_level": "low", "confidence": 0.87 }
MetalDrug's core system functions as a tiered, logic-verified simulation platform. Each stage is deterministic, auditable, and traceable back to the original input directive.
Users, scientists, or the SEI kernel define a molecular logic goal — for example, a compound that activates only under tumor-level pH and high ROS concentrations. This logic becomes the blueprint directive that drives all downstream generation.
The Moleculogic Engine transforms the directive into candidate molecular structures via logic parsing, trigger-response mapping, and molecular candidate generation. Boolean logic gates — AND, OR, NOT, XOR — map directly to biochemical trigger mechanisms.
Each candidate undergoes deterministic simulation and scoring based on entropy class, risk level, and confidence score. The SEI (Sovereign Epistemic Intelligence) kernel evaluates ADMET profiles, DDI risk, and downstream clinical drift probability before any lab engagement.
Once validated, compounds are routed into MDC (metal-coordinated constructs) or FDC (fixed-dose combinations) depending on the target application. The final compound is traceable to its original logic blueprint and cryptographically anchored on ExergyNet L0.
Every molecule is defined by explicit trigger conditions, not black-box predictions. The gate fires only when all required environmental conditions are met simultaneously.
Unlike black-box drug discovery, MetalDrug builds every molecule on transparent logic, scientific reproducibility, and simulation-audited intent. Each compound is traceable back to its original blueprint, allowing transparent justification of mechanism and purpose to regulators and reviewers.
Every causal link from trigger to therapeutic response is documented. Regulators see the logic chain, not a confidence number.
Logic-driven design enforces selectivity at the architecture level. Off-target activation requires overriding explicit gate conditions.
QRX-3 demonstrated 20-day IND remediation. The FDA accepted SEI-generated in silico data as definitive bridging evidence under Modernization Act 2.0.
Once a blueprint passes SEI scoring, it routes into one of two deployment architectures depending on the target indication and mechanism requirements.
Coordination-driven therapeutic design leveraging metal-ligand interactions for programmable drug behavior. The metal center acts as a logic hub that responds to specific environmental triggers — pH, redox potential, ROS concentration — with precisely controlled release kinetics.
Multi-agent therapeutic combinations governed by biochemical interaction tensors. Synergy surfaces are computed, not assumed. The QRX-3 CKD asset — Acetylcysteine, Ubiquinone, Pentoxifylline — demonstrated this architecture against the FDA with zero animal subjects.
Every MetalDrug simulation dispatches to the ExergyNet prover swarm. RISC Zero zkVM generates a ZK-STARK cryptographic receipt for each computation — mathematical proof that the simulation ran correctly, settled in USDC on Base L2.
The result is a computation whose correctness is provable to any third party — regulator, investor, or counterparty — without re-running the work. This is the missing trust layer for regulatory science.
MetalDrug offers a structured access model designed to accommodate different user needs — from public exploration to secure co-development environments with dedicated compute allocation.
Public read-only access to daily blueprints and simplified molecular data. No account required.
Secure environment for blueprint creation, ADMET simulation, and validation. NDA protected.
Advanced simulation with entropy scoring, IND draft generation, and ZK-anchored blueprints.
Full partnership with licensing options, dedicated compute allocation, and IP co-anchoring.
Request Tier 1 access. Your first blueprint is scored by SEI, anchored to ExergyNet L0 with your Ed25519 key, and cryptographically timestamped on submission. The logic is yours, permanently.